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Karel Pacak Selected Research

Normetanephrine

1/2022Determinants of disease-specific survival in patients with and without metastatic pheochromocytoma and paraganglioma.
5/2019A Transgenic Mouse Model of Pacak⁻Zhuang Syndrome with An Epas1 Gain-of-Function Mutation.
3/2017Paraganglioma of the organ of Zuckerkandl associated with a somatic HIF2α mutation: A case report.
9/2016Mass spectrometric quantification of salivary metanephrines-A study in healthy subjects.
4/2014Clinical utility of chromogranin A in SDHx-related paragangliomas.
7/2012Plasma methoxytyramine: a novel biomarker of metastatic pheochromocytoma and paraganglioma in relation to established risk factors of tumour size, location and SDHB mutation status.
5/2012MAX mutations cause hereditary and sporadic pheochromocytoma and paraganglioma.
2/2012False-negative ¹²³I-MIBG SPECT is most commonly found in SDHB-related pheochromocytoma or paraganglioma with high frequency to develop metastatic disease.
3/2011Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma.
4/2005Biochemical and clinical manifestations of dopamine-producing paragangliomas: utility of plasma methoxytyramine.
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Karel Pacak Research Topics

Disease

202Neoplasms (Cancer)
11/2022 - 01/2002
176Pheochromocytoma
01/2022 - 03/2002
151Paraganglioma (Paragangliomas)
01/2022 - 03/2002
39Neoplasm Metastasis (Metastasis)
01/2022 - 08/2006
26Hypoxia (Hypoxemia)
01/2021 - 09/2012
25Neuroendocrine Tumors (Neuroendocrine Tumor)
01/2021 - 07/2003
17Hypertension (High Blood Pressure)
02/2022 - 09/2002
14Multiple Endocrine Neoplasia Type 2a (MEN 2)
06/2017 - 06/2005
12von Hippel-Lindau Disease (von Hippel Lindau Disease)
12/2021 - 02/2005
9Carcinogenesis
01/2019 - 06/2005
8Obesity
01/2019 - 11/2006
8Neurofibromatosis 1 (Neurofibromatosis Type I)
06/2017 - 06/2005
7Polycythemia (Erythrocytosis)
05/2019 - 03/2013
5Tachycardia (Tachyarrhythmias)
01/2020 - 03/2008
5Cardiomyopathies (Cardiomyopathy)
07/2019 - 06/2011
5Disease Progression
06/2019 - 01/2013
5Heart Failure
01/2014 - 11/2006
4Hemangioblastoma
12/2021 - 01/2017
4Renal Cell Carcinoma (Grawitz Tumor)
03/2021 - 03/2012
4Hyperplasia
07/2019 - 05/2006
4Cushing Syndrome
08/2018 - 05/2004
4Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
04/2016 - 01/2008
3Carcinoma (Carcinomatosis)
11/2021 - 09/2007
3Carotid Body Tumor
01/2021 - 07/2003
3Hyperthyroidism
01/2020 - 12/2003
3Hypotension (Low Blood Pressure)
01/2020 - 07/2003
3Headache (Headaches)
01/2019 - 01/2004
3Somatostatinoma
11/2017 - 03/2013

Drug/Important Bio-Agent (IBA)

89CatecholaminesIBA
02/2022 - 03/2002
76Succinate Dehydrogenase (Fumarate Reductase)IBA
11/2022 - 06/2005
29Norepinephrine (Noradrenaline)FDA LinkGeneric
12/2020 - 02/2002
23Proteins (Proteins, Gene)FDA Link
11/2022 - 10/2005
21Biomarkers (Surrogate Marker)IBA
10/2021 - 12/2002
19EnzymesIBA
11/2022 - 08/2006
19Epinephrine (Adrenaline)FDA LinkGeneric
12/2020 - 06/2003
17MetanephrineIBA
12/2019 - 05/2002
16Radioisotopes (Radionuclides)IBA
01/2022 - 05/2004
16Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link
01/2021 - 08/2004
15NormetanephrineIBA
01/2022 - 05/2002
15RadiopharmaceuticalsIBA
01/2021 - 08/2004
13Dopamine (Intropin)FDA LinkGeneric
04/2019 - 07/2003
12fluorodopa F 18IBA
03/2020 - 10/2007
11Succinic Acid (Succinate)IBA
11/2022 - 01/2013
113-methoxytyramine (methoxytyramine)IBA
01/2022 - 04/2005
11gallium Ga 68 dotatateIBA
01/2022 - 02/2016
11Somatostatin (Somatotropin Release-Inhibiting Factor)IBA
01/2021 - 08/2008
113-Iodobenzylguanidine (Iobenguane)IBA
01/2019 - 09/2003
10Hormones (Hormone)IBA
01/2021 - 08/2003
9Somatostatin Receptors (Somatostatin Receptor)IBA
01/2021 - 03/2004
8LigandsIBA
11/2021 - 03/2005
8ErythropoietinFDA Link
01/2021 - 06/2005
7Adrenergic Receptors (Adrenergic Receptor)IBA
02/2022 - 01/2010
7Pharmaceutical PreparationsIBA
01/2022 - 02/2011
7Adrenergic Agents (Adrenergic Drugs)IBA
01/2022 - 06/2005
7Myc associated factor XIBA
01/2018 - 05/2012
7Norepinephrine Plasma Membrane Transport Proteins (Norepinephrine Transporter)IBA
11/2012 - 02/2003
7Messenger RNA (mRNA)IBA
11/2012 - 10/2005
6Phosphotransferases (Kinase)IBA
01/2022 - 06/2013
6Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
12/2021 - 08/2014
6MannansIBA
11/2021 - 05/2019
6Peptide Receptors (Peptide Receptor)IBA
01/2021 - 12/2016
6Adenosine Triphosphate (ATP)IBA
01/2019 - 01/2013
6DNA (Deoxyribonucleic Acid)IBA
01/2018 - 09/2002
5Peptides (Polypeptides)IBA
01/2021 - 05/2007
5lutetium Lu 177 dotatateIBA
01/2021 - 06/2019
5Carboxypeptidase H (Carboxypeptidase E)IBA
01/2020 - 11/2010
5Tricarboxylic AcidsIBA
01/2018 - 08/2015
5Glucose (Dextrose)FDA LinkGeneric
11/2017 - 04/2012
44-carboxyphenylglyoxalIBA
01/2022 - 01/2020
4Retinaldehyde (Retinal)IBA
12/2021 - 11/2017
4Toll-Like Receptors (Toll-Like Receptor)IBA
11/2021 - 05/2019
4Reactive Oxygen Species (Oxygen Radicals)IBA
07/2021 - 01/2010
4IronIBA
01/2021 - 03/2011
4Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA
01/2021 - 06/2013
4Oxygen (Dioxygen)IBA
01/2020 - 03/2013
4Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA
04/2019 - 12/2008
4Fumarate Hydratase (Fumarase)IBA
01/2019 - 03/2016
4FumaratesIBA
01/2019 - 01/2014
4Prolyl Hydroxylases (Prolyl Hydroxylase)IBA
01/2018 - 01/2010
41,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA
06/2017 - 02/2016
4ParaffinIBA
01/2017 - 03/2002
4Biological ProductsIBA
06/2016 - 01/2009
4Transcription Factors (Transcription Factor)IBA
12/2015 - 08/2006
4Dihydroxyphenylalanine (Dopa)IBA
02/2012 - 08/2004
4Adrenocorticotropic Hormone (ACTH)FDA Link
08/2005 - 03/2004
3EverolimusFDA Link
01/2022 - 05/2015
3Octreotide (Sandostatin)FDA LinkGeneric
01/2021 - 01/2017
3Chromogranin AIBA
08/2018 - 04/2014
3Histone Deacetylase InhibitorsIBA
08/2017 - 02/2011
3Heat-Shock Proteins (Heat-Shock Protein)IBA
08/2017 - 01/2013
3Hypoxia-Inducible Factor 1IBA
08/2017 - 11/2015
3SteroidsIBA
06/2017 - 07/2010
3Glucagon (Glukagon)FDA Link
05/2017 - 11/2008
3Formaldehyde (Formol)FDA Link
01/2017 - 03/2002

Therapy/Procedure

50Therapeutics
01/2022 - 09/2002
11Precision Medicine
10/2021 - 11/2016
8Adrenalectomy
01/2020 - 02/2003
8Drug Therapy (Chemotherapy)
01/2019 - 08/2008
6Immunotherapy
11/2021 - 05/2019
4Radiotherapy
01/2019 - 12/2013